Fixed combination has recently made a
comeback as an initial therapy in the
treatment of hypertension. The additive
or synergistic effect of combination
therapy fully lowers blood pressure in
patients who tend to have less than full
response to one component only.
Antihypertensive monotherapy does not
address the multifactorial nature of
hypertension as a disease with many
pathways; using more than one drug makes
more therapeutic sense, as combined
agents cover more than one etiology.
